CALL FOR PAPERS Mitochondria in Cardiovascular Physiology and Disease Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload
نویسندگان
چکیده
James D. Gladden, Blake R. Zelickson, Jason L. Guichard, Mustafa I. Ahmed, Danielle M. Yancey, Scott Ballinger, Mayilvahanan Shanmugam, Gopal J. Babu, Michelle S. Johnson, Victor Darley-Usmar, and Louis J. Dell’Italia University of Alabama at Birmingham (UAB) Comprehensive Cardiovascular Center, UAB Birmingham, Alabama; Department of Medicine, Division of Cardiovascular Disease, UAB, Birmingham, Alabama; Department of Pathology, UAB, Birmingham, Alabama; UAB Center for Free Radical Biology, UAB, Birmingham, Alabama; Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, Newark, New Jersey; and Department of Veterans Affairs Medical Center, Birmingham, Alabama
منابع مشابه
Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload.
Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of increased ATP demand, XO-mediated ROS can decrease mitochondrial respiration and contractile function. Thus, we tested the hypothesis that XO inhibition improves cardiomyocyte bioenergetics and LV function in chronic...
متن کاملRight ventricular Hemodynamic Alteration after Pulmonary Valve Replacement in Children with Congenital Heart Disease
Introduction: In patients who underwent surgery to repair Tetralogy of Fallot, right ventricular dilation from pulmonary regurgitation may be result in right ventricular failure, arrhythmias and cardiac arrest. Hence, pulmonary valve replacement may be necessary to reduce right ventricular volume overload. The aim of present study was to assess the effects of pulmonary valve replacement on rig...
متن کاملThe Correlation between Left and Right Ventricular Ejection Fractions in Patients with Ischemic Heart Disease, Documented by Cardiac Magnetic Resonance Imaging
Introduction: The correlation between right and left ventricular ejection fractions (RVEF and LVEF, respectively) has been studied in only a small number of patients with a marked decrease in RVEF and LVEF. The aim of the present study was to compare LVEF and RVEF in patients with ischemic heart disease. RVEF and LVEF were measured by Cardiovascular Magnetic Resonance (CMR) imaging. Materials a...
متن کاملبررسی عوارض قلبی در بیماران مبتلا به تالاسمی ماژور در کاشان در سالهای 1378 لغایت 1379
ABSTRACT Due to the frequency of major thalassemia in our country and cardiac complications secondry to iron overload as one of the most important causes of death in these patients and the absence of any similar study in this region (Kashan city), we studied the cardiac complications in patients with major thalassemia in Kashan in 1999 and 2000. A prospective descriptive study was perf...
متن کاملEchocardiographic Evaluation of left Ventricular Function and Geometry in Pediatric Patients with Kidney Transplantation
Extended abstract Echocardiographic Evaluation of Left Ventricular Function and Geometry in Pediatric Patients with Kidney Transplantation Cardiovascular disease (CVD) is an important, leading cause of mortality and morbidity in patients with chronic kidney disease (CKD) as well as in renal transplant recipients. Cardiovascular complications become more important in children because of the i...
متن کامل